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how can i get rid of runtime error 21?

everytime i start up my computer i get 2 boxes with runtime error 21. how can i fix it. have tried using spybot search and destroy but no joy.
kaz bryson, August 2008
You could try this.

http://simple-pc-help.com/support/runtime_21.html?t202id=1198&t202kw=runtime%20error%2021&gclid=CMzl9-rP-ZUCFRU7EAod63P_Dw

Glen, September 2008