try to perform the action mention below. If not happen then visit on the this link..for detail.http://www.iyogi.co.uk
The connection to port 25 on your domain times out.
If the port 25 is blocked, you need to use the ISP's mail server as outgoing mail server to send out emails from your email clients.
If you are a Deru Customer, you can still send emails using your domain, but using port 26 for smtp.
Following are the steps to change the smtp port to 26 on your outlook express.
1. Open Outlook express
2. Click on Tool -> Accounts
3. Highlight the account and click on Properties
4. Select Advanced tab
5. Under Server Port Numbers, change Outgoing mail (SMTP) port to 26
6. Click on Apply and OK to save the changes
PRINCE, June 2009