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I've got a message" Your system is infected" on my desktop?

The message come on with my desktop and I cannot remove it.I have scanned my pc with zonealarm and it quarantined and /or removed some viruses.I have disabled all of my start up programs but it still is there.The pop up little red button with the x telling me to click here to fix it on the start up icon bar has gone but the red message on a black rectangle is still there.I have a Dell Dimension DXC 061 PC running using windows XP
James Mc Dowell, July 2009
Sounds like a Malware infection. Most AVs like Zone Alarm amongst others arnt great a removing Malware.

I would suggest something like Malware Bytes Anti Malware. Its not an Antivirus suite like ZA is but its an on demand scanner that generally is a lot better for this type of situation.

Seen this program pick up hundreds of items missed by standard AVs

Phil Roberts, July 2009
link Click here to see other fixes for Dell.