when you say you have tried other mice and keyboards, have you tried a usb rather than ps2 connections?
if you are using a usb keyboard,mouse combo it could be software or hardware, test using a usb stick or some such, if you are using the other type it could be a faulty connection or other hardware problem.
Try starting in safe mode/using a linux boot disc to see if it is a problem with the operating system itself.
report back.
good luck
R, May 2010