Press CLEAR (CL) and see if the E disappears. If not, you probably have a keyboard fault such as spillage. If you can clear the error, press subtotal then total.
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For those asking about a Sharp ER-A330 manual, one of the users has it here:
http://the-checkout-tech.com/manuals/cashregisters/Sharp_ER-A330_instruction_manual.html
Registerman, June 2013