Make sure power is off at the breaker and test the room for power after it is off to be sure. Remove old fixture, the two blacks together put with black on new fixture, there should be a white wire in the box that is neutral, put with the white wire on new fixture. The blue wire on the fixture is usually for lights on the fixture, put with the black wires. The e.brown, if it is a bare wire with no coating, it is ground. Ground to fixture and to box, if metal box. The red wires are usually used for passing power on three-way switches, no need to hook up.
Paul, July 2007