Just some ideas:
1. If it is an old rollerball style mouse, take out the ball and brush off any dust/hairs etc. from the ball itself.
2. If it is a wireless mouse, try changing the channel on the receiver and the mouse.
3. Try using a different USB port for the mouse
4. Just in case it is an odd virus, try running a virus scanner on your machine (AVG is a good, free one).
Nemesis, March 2008