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How can i fix my pendrive to register when i plug it in?

Hi,
my pendrive, Kingston
does not register/ come up on the computer when i plug it in? It doesnt say anything in my computer at all?
Does anyone have any suggestions, ideas, tips or knowledge etc?? I would be sooooooo grateful if you did because i urgently need my pendrive to work.
Thanks,
eleanor, January 2010